Emergency services were called to the Bruce Highway near Rangemore Road at Gumlu, about 135 kilometres south of Townsville, about 4pm today after reports the large coach had rolled.
Queensland Ambulance paramedics were assessing 30 people at the scene.
The person who died was a passenger, police said.
Multiple other passengers have been taken to hospitals in Ayr, Bowen and Townsville.
The bus driver, a 70-year-old Mackay man, was transported to Bowen Hospital with minor injuries.
The Forensic Crash Unit is investigating the single vehicle crash and has appealed for any witnesses to come forward.
The road was closed to all traffic in both directions and motorists were being told to avoid the area.
In that crash, three women aged 56, 33 and 21 died, while several other bus passengers were injured.
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